Abstract

Leukemia is a fatal disease that threatens the lives of many patients. Early detection can effectively improve its rate of remission. This paper proposes two automated classification models based on blood microscopic images to detect leukemia by employing transfer learning, rather than traditional approaches that have several disadvantages. In the first model, blood microscopic images are pre-processed; then, features are extracted by a pre-trained deep convolutional neural network named AlexNet, which makes classifications according to numerous well-known classifiers. In the second model, after pre-processing the images, AlexNet is fine-tuned for both feature extraction and classification. Experiments were conducted on a dataset consisting of 2820 images confirming that the second model performs better than the first because of 100% classification accuracy.

Highlights

  • Diagnosis is performed by a physician to detect the presence or absence of a certain disease in a patient according to a particular dataset, which may include signs, symptoms, medical images, and exams

  • A 2012 study showed that about 352,000 adults and children all over the world develop leukemia, which starts in the bone marrow and is distinguished by the number of white cells increasing in an abnormal manner [1]

  • This paper proposes two classification models that are based on transfer learning and can distinguish between healthy and unhealthy blood smear images with high accuracy

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Summary

Introduction

Diagnosis is performed by a physician to detect the presence or absence of a certain disease in a patient according to a particular dataset, which may include signs, symptoms, medical images, and exams. A 2012 study showed that about 352,000 adults and children all over the world develop leukemia, which starts in the bone marrow and is distinguished by the number of white cells increasing in an abnormal manner [1] This disease has several causes, such as exposure to radiation and certain chemicals, as well as family history [6]. This paper proposes two classification models that are based on transfer learning and can distinguish between healthy and unhealthy blood smear images with high accuracy. These models employ AlexNet, which is a deep CNN that achieved huge success in the image classification challenge, ImageNet 2012.

Related Studies
Traditional Methods
Deep-Learning-Based Methods
Method
Image Pre-ProcessingFigure
Image Pre-Processing
Feature
Second Classification Model
Experiments
Dataset
Implementation and Experiments
Methods
Findings
Discussion
Conclusions and Future Studies
Full Text
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