Deep tissue perineal candida glabrata infection, related to sodium-glucose cotransporter 2 (SGLT-2) inhibitor dapagliflozin

Abstract

Fournier’s gangrene is a rare and serious event, primarily caused by bacteria. Candida species, mainly Candida albicans (C.al) are infrequently isolated, usually as a part of polymicrobial infection. Non-C.al Fournier’s gangrene was reported in immunocompromised and diabetic patients. We report a case of a 60-year-old man with diabetes mellitus, who recently initiated treatment with SGLT-2 inhibitor presenting with perineal soft-tissue infection. Tissue cultures yielded Candida Glabrata as the sole pathogen. The patient received antibacterial and appropriate antifungal therapy, concurrent with surgical debridement. Yeast infection should be considered in diabetes patients under SGLT-2 therapy presenting with a deep tissue infection.