Abstract
Risk (or susceptibility) alleles for primary membranous nephropathy exist within the DQ and DR loci of the human leukocyte antigen (HLA) region of chromosome 6. The discussed study identifies a novel allele, HLA DRB1*1502, in a Han Chinese cohort that acts as a modifier allele by associating not with the phenotype of membranous nephropathy, but rather with the severity of disease. This commentary addresses the potential biologic aspects of these new data.
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