Abstract
For successful signaling, Ras associates with its downstream effector, Raf. Ras dimerization likely plays an important role in this process, as the active form of Raf is known to be a dimer. However, it is still unclear whether Ras dimerizes first, facilitating the Raf dimerization and further downstream signaling, or a different sequence of events is in play. Given the conformational heterogeneity in both Ras and Raf, probing their dimerization mechanism experimentally is difficult. Hence, we used simulations and deep learning methods to characterize the Ras dimerization interface.
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