Deep Learning in the Inflammation in Alzheimer’s Disease

Abstract

Alzheimer's disease (AD) refers to the most prevalent neurological disease, which is caused by amyloid plaque deposition and tau tangles accumulation. Several recent clinical investigations have suggested that many immune system components may play essential roles in AD pathogenesis. Both adaptive and innate immune system shows a bi-directional regulation to AD and the over-activated immune system could lead to neurons’ inflammation. In this article, the critical role of microglia in the non-specific immune system and T lymphocytes in specific immune system are mainly focused. Microglia and T cells both play important roles in regulating the cytokines and multiple signaling pathways which are associated with memory loss. Other immune cells including B lymphocytes and neutrophils are possibly associated with the pathology of AD, although their roles still need to be studied. Here, research showing the link among dysfunctional immune cells and AD pathophysiology are reviewed in this project. In addition, the potential treatment and therapeutics target for AD are also discussed.