Abstract

Quantitative assessments of patient movement quality in osteoarthritis (OA), specifically spatiotemporal gait parameters (STGPs), can provide in-depth insight into gait patterns, activity types, and changes in mobility after total knee arthroplasty (TKA). A study was conducted to benchmark the ability of multiple deep neural network (DNN) architectures to predict 12 STGPs from inertial measurement unit (IMU) data and to identify an optimal sensor combination, which has yet to be studied for OA and TKA subjects. DNNs were trained using movement data from 29 subjects, walking at slow, normal, and fast paces and evaluated with cross-fold validation over the subjects. Optimal sensor locations were determined by comparing prediction accuracy with 15 IMU configurations (pelvis, thigh, shank, and feet). Percent error across the 12 STGPs ranged from 2.1% (stride time) to 73.7% (toe-out angle) and overall was more accurate in temporal parameters than spatial parameters. The most and least accurate sensor combinations were feet-thighs and singular pelvis, respectively. DNNs showed promising results in predicting STGPs for OA and TKA subjects based on signals from IMU sensors and overcomes the dependency on sensor locations that can hinder the design of patient monitoring systems for clinical application.

Highlights

  • Quantitative assessments of movement quality in osteoarthritic (OA) and joint reconstruction patients, spatial-temporal gait parameters (STGPs), provide valuable insight into gait patterns, activity type [1], risk of falling, and disease progression [2,3]

  • OA patients demonstrated greater variation (standard deviation (SD), coefficient of variation (CV), and range) in all but two of the STGPs measured compared to total knee arthroplasty (TKA) patients

  • A design of experiment conducted on 15 combinations of sensors and locations for different patient populations and gait paces revealed how the prediction accuracy of STGPs can change over different conditions and identification of an optimal sensor combination might be challenging

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Summary

Introduction

Quantitative assessments of movement quality in osteoarthritic (OA) and joint reconstruction patients, spatial-temporal gait parameters (STGPs), provide valuable insight into gait patterns, activity type [1], risk of falling, and disease progression [2,3]. This diagnostic information is used in a number of applications that include development of personalized treatment plans, optimized post-operative rehabilitation, monitoring changes in mobility of patients after surgery [4,5,6,7], advancement of promising new interventions, and reducing overall medical costs [2]

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