Abstract

Adverse event detection is critical for many real-world applications including timely identification of product defects, disasters, and major socio-political incidents. In the health context, adverse drug events account for countless hospitalizations and deaths annually. Since users often begin their information seeking and reporting with online searches, examination of search query logs has emerged as an important detection channel. However, search context - including query intent and heterogeneity in user behaviors - is extremely important for extracting information from search queries, and yet the challenge of measuring and analyzing these aspects has precluded their use in prior studies. We propose DeepSAVE, a novel deep learning framework for detecting adverse events based on user search query logs. DeepSAVE uses an enriched variational autoencoder encompassing a novel query embedding and user modeling module that work in concert to address the context challenge associated with search-based detection of adverse events. Evaluation results on three large real-world event datasets show that DeepSAVE outperforms existing detection methods as well as comparison deep learning auto encoders. Ablation analysis reveals that each component of DeepSAVE significantly contributes to its overall performance. Collectively, the results demonstrate the viability of the proposed architecture for detecting adverse events from search query logs.

Highlights

  • Adverse event detection has become a critical component of post-marketing surveillance in many contexts including pharmaceutical drugs, children’s toys, and the automotive industry [2]

  • DeepSAVE was close to other methods on the Food and Drug Administration (FDA) and National Highway Transportation Safety Agency (NHTSA) test beds

  • The results underscore the effectiveness of DeepSAVE for search-based adverse event detection relative to Disproportionality AnalysisDisproportionality Analysis (DA), association rule, classifier, and standard Variational auto encoders (VAE) methods

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Summary

Introduction

Adverse event detection has become a critical component of post-marketing surveillance in many contexts including pharmaceutical drugs, children’s toys, and the automotive industry [2]. In the automotive industry, Toyota recently settled lawsuits totaling nearly $6 billion for inadequate rust protection on their trucks, and the unintended acceleration “sticky pedal” fiasco [2] Such surveillance has implications for other types of events, including sociopolitical incidents and natural disasters [42] [24]. Specific examples of DA measures proposed in the literature are Reporting Odds Ratio (ROR), Relative Reporting Ratio (RRR), Proportional Reporting Ratio (PRR) and Information Component (IC) [33] [8]. DA methods have typically yielded low precision and recall for adverse event detection [2] [3]

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