Abstract
Human infertility is considered as a serious disease of the reproductive system that affects more than 10% of couples across the globe and over 30% of the reported cases are related to men. The crucial step in the assessment of male infertility and subfertility is semen analysis that strongly depends on the sperm head morphology, i.e., the shape and size of the head of a spermatozoon. However, in medical diagnosis, the morphology of the sperm head is determined manually, and heavily depends on the expertise of the clinician. Moreover, this assessment as well as the morphological classification of human sperm heads are laborious and non-repeatable, and there is also a high degree of inter and intra-laboratory variability in the results. In order to overcome these problems, we propose a specialized convolutional neural network (CNN) architecture to accurately classify human sperm heads based on sperm images. It is carefully designed with several layers, and multiple filter sizes, but fewer filters and parameters to improve efficiency and effectiveness. It is demonstrated that our proposed architecture outperforms state-of-the-art methods, exhibiting 88% recall on the SCIAN dataset in the total agreement setting and 95% recall on the HuSHeM dataset for the classification of human sperm heads. Our proposed method shows the potential of deep learning to surpass embryologists in terms of reliability, throughput, and accuracy.
Highlights
Human infertility is considered as a serious disease of the reproductive system that affects more than 10% of couples across the globe and over 30% of the reported cases are related to men
For illustration (Figure 2), we show typical of human sperm heads For of microscopic
2), we show typical samples of human sperm heads of microscopic images of the five classes in images of the five classes in the partial agreement setting of the SCIAN dataset and the four classes thethe partial agreement setting of the SCIAN dataset and the four classes of the Human Sperm Head Morphology (HuSHeM) dataset
Summary
Human infertility is considered as a serious disease of the reproductive system that affects more than 10% of couples across the globe and over 30% of the reported cases are related to men. In medical diagnosis, the morphology of the sperm head is determined manually, and heavily depends on the expertise of the clinician This assessment as well as the morphological classification of human sperm heads are laborious and non-repeatable, and there is a high degree of inter and intra-laboratory variability in the results. In order to overcome these problems, we propose a specialized convolutional neural network (CNN) architecture to accurately classify human sperm heads based on sperm images. It is carefully designed with several layers, and multiple filter sizes, but fewer filters and parameters to improve efficiency and effectiveness. Human spermatozoon is the gamete−the male reproductive cell−that may fertilize the mature probability that one of the sperm in the semen unites an egg to form a zygote significantly decreases
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
