Abstract

In the recent past, the Classifiers are based on genetic signatures in which many microarray studies are analyzed to predict medical results for cancer patients. However, the Signatures from different studies have been benefitted with low-intensity ratio during the classification of individual datasets has been considered as a significant point of research in the present scenario. Hence to overcome the above-discussed issue, this paper provides a Deep Learning Framework that combines an algorithm of necessary processing of Linear Discriminant Analysis (LDA) and Auto Encoder (AE) Neural Network to classify different features within the profile of gene expression. Hence, an advanced ensemble classification has been developed based on the Deep Learning (DL) algorithm to assess the clinical outcome of breast cancer. Furthermore, numerous independent breast cancer datasets and representations of the signature gene, including the primary method, have been evaluated for the optimization parameters. Finally, the experiment results show that the suggested deep learning frameworks achieve 98.27% accuracy than many other techniques such as genomic data and pathological images with multiple kernel learning (GPMKL), Multi-Layer Perception (MLP), Deep Learning Diagnosis (DLD), and Spatiotemporal Wavelet Kinetics (SWK).

Highlights

  • Breast cancer seems to be the most common type of cancer that women around the world, and it is found in developed countries after lung cancer [1]

  • This study indicates that Deep Learning Diagnosis (DLD) can make clinical decisions on breast cancer easier by recognizing cases with a significant risk of misdiagnosis

  • EXPERIMENTAL RESULTS AND DISCUSSION Compared to the Linear Discriminant Analysis (LDA)&Auto Encoder (AE)-DL classification performance with those of other classifiers, the LDA-AE works better than other methods such as GPMKL, Multi-Layer Perception (MLP), DLD, Spatiotemporal Wavelet Kinetics (SWK), which are built with LDA compressed features for all the evaluation metrics

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Summary

Introduction

Breast cancer seems to be the most common type of cancer that women around the world, and it is found in developed countries after lung cancer [1]. In all over the world, 50% to 60% of cases of breast cancer occur in late stages, and patients have one of the lowest survival levels in the region [2], [3]. There is a need to determine multiple factors that affect the survival rate of breast cancer patients. Clinicians are using basic Software programs for analyzing factors influencing breast cancer survival rates. Such traditional statistical methods cannot be modified to identify new variables or create innovative and inclusive visualizations. Different approaches to machine learning (ML) [4] are used in this area as decision tree (DT) random forest (RF)

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