Abstract
Background Continued debates exist regarding the optimal temperature during hypothermic circulatory arrest in aortic arch repair for patients with type A aortic dissection. This study seeks to examine whether the use of moderate hypothermic circulatory arrest in a pig model provides comparable vital organ protection outcomes to the use of deep hypothermic circulatory arrest. Methods Thirteen pigs were randomly assigned to 30 minutes of hypothermic circulatory arrest without cerebral perfusion at 15°C (n = 5), 25°C (n = 5), and a control group (n = 3). The changes in standard laboratory tests and capacity for protection against apoptosis in different vital organs were monitored with different temperatures of hypothermic circulatory arrest management in pig model to determine which temperature was optimal for hypothermic circulatory arrest. Results There were no significant differences in the capacity for protection against apoptosis in vital organs between 2 groups (p > 0.05, respectively). Compared with the moderate hypothermic circulatory arrest group, the deep hypothermic circulatory arrest group had no significant advantages in terms of the biologic parameters of any other organs (p > 0.05). Conclusions Compared with deep hypothermic circulatory arrest, moderate hypothermic circulatory arrest is a moderate technique that has similar advantages with regard to the levels of biomarkers of injury and capacity for protection against apoptosis in vital organs.
Highlights
Acute aortic dissection (AAD) is a serious and rapidly progressing vascular disease that has features of acute onset and poor prognosis
Many scholars have abandoned traditional deep hypothermic circulatory arrest (DHCA) and adopted moderate hypothermic circulatory arrest (MHCA) or even mild hypothermic circulatory arrest combined with cerebral perfusion, but these attempts lack a foundation [5, 6]
There were no significant differences in the apoptosis index and positive cell rate of Bax, caspase3, and Bax/Bcl-2, which still indicated a similar capacity for protection against apoptosis in the lung under different HCA conditions (Figures 5, 6, and 7)
Summary
Acute aortic dissection (AAD) is a serious and rapidly progressing vascular disease that has features of acute onset and poor prognosis. Surgical operation under moderate to deep hypothermic circulatory arrest (DHCA) is the most effective treatment for this disease to avoid or reduce the ischemia and anoxia of vital organs caused by circulatory arrest. This study seeks to examine whether the use of moderate hypothermic circulatory arrest in a pig model provides comparable vital organ protection outcomes to the use of deep hypothermic circulatory arrest. The changes in standard laboratory tests and capacity for protection against apoptosis in different vital organs were monitored with different temperatures of hypothermic circulatory arrest management in pig model to determine which temperature was optimal for hypothermic circulatory arrest. Compared with deep hypothermic circulatory arrest, moderate hypothermic circulatory arrest is a moderate technique that has similar advantages with regard to the levels of biomarkers of injury and capacity for protection against apoptosis in vital organs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
