Abstract
Thermodynamic investigations provide information about the solute-solvent interactions in the selection of the proper solvent for different fields of pharmaceutical sciences. Especially, the study of antiepileptic drugs in solutions (ethanol/co-solvent) has been a subject of interest owing to their effect in the systems using interaction with a number of important biological membranes. This work focuses on the measurement of density and speed of sound of the phenytoin (PTH) in ethanol/deep eutectic solvents (choline chloride:ethylene glycol, and choline chloride:glycerol) solutions as the innovative class of green solvents at temperature range (288.15 to 318.15) K. It was determined Hansen solubility parameters for assessment of PTH interactions in the solvent media. Some thermophysical parameters including apparent molar volumes Vϕ, apparent molar isobaric expansion E_varphi^0, and Hepler’s constant, apparent molar isentropic compressibility κφ were obtained and calculated using these data. To correlate the Vϕ and κφ values, the Redlich-Meyer equation was used to calculate the number of quantities containing standard partial molar volume and partial molar isentropic compressibility. Finally, Delta delta values showed a strong interaction between PTH and solvent (ethanol/DES (ChCl:EG)). The thermodynamic analysis of the studied system also plays a crucial role in the pharmaceutical industry.
Highlights
Thermodynamic investigations provide information about the solute-solvent interactions in the selection of the proper solvent for different fields of pharmaceutical sciences
Poor solubility is a chief limitation to oral delivery of numerous emerging drugs and bioavailability is significantly affected by the drug s olubility[1,2]
Solubility of several drugs in the presence of various deep eutectic solvents (DESs) has been reported in our previous works, and the results show a significant increase in the solubility of drugs
Summary
Thermodynamic investigations provide information about the solute-solvent interactions in the selection of the proper solvent for different fields of pharmaceutical sciences. The apparent molar volumes Vφ of binary PTH/ethanol and ternary PTH/ethanol/DESs (ChCl:Gly, and ChCl:EG) in diverse DES molalities (0.5, 1, and 1.5 mol k g-1) were calculated using the measurements of density d data. The PTH is defined as a solute, and DESs are introduced as co-solvent.
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