Abstract
One-pot synthesis of hydrazinyl-4-phenyl-1,3-thiazole derivatives was developed by three-component reaction of various ketones or aldehydes, phenacyl chloride, and thiosemicarbazid in the presence of choline chloride/urea as a deep eutectic solvent (DES) at 70 °C. The products formed in excellent yields over short reaction times under an environmentally friendly condition. This method develops by using an environmentally benign synthetic method along with the use of a cost-effective catalyst. The study of antibacterial activity revealed that the compounds (4j, 4k, 4l, 4m, 4s, and 4t) showed good inhibition toward Escherichia coli.
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