Abstract
The development of deep eutectic solvent (DES) as a green medium and catalyst for sustainable organic synthesis is expanding due to environmental consciousness. DES components are inexpensive, easy to synthesize, non-toxic, biodegradable, and have tunable physicochemical properties. In this study, DESs were formed by a mixture of choline chloride (ChCl) as a hydrogen bond acceptor (HBA), while oxalic acid, glycerol, and urea acted as hydrogen bond donors (HBD). The formed DESs were then characterized by FTIR and their physicochemical properties. DES was applied as a catalyst in the esterification reaction of hydroxyphenylglycine (HPG) to produce hydroxyphenylglycine methyl ester (HPGME), an intermediate material for beta-lactam antibiotics. The result demonstrated that using DES consisting of ChCl-oxalic acid (1:1) could produce HPGME with a yield of 40%. However, further research is essential to investigate the optimum reaction condition, such as the composition of added DES, reaction time, and temperature to obtain a higher yield of HPGME.
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