Abstract
Fluorapatite (FA) nanoparticles were synthesized via an one-step and green pathway by employing the deep eutectic solvent based on choline chloride-CaCl2.6H2O. In an innovative approach, the eutectic solvent was chosen in such a way to act as solvent, reactant and template, simultaneously. The results obtained from characterization of the as-synthesized nanoparticles revealed the formation of FA nanoparticles having average crystal size of 26nm, percent crystallinity of 99%, mean particle size of 30nm, and high crystal, elemental, and structural purity. In vitro study was conducted by immersion of FA nanoparticles in SBF solution. The results obtained by SEM, EDS, FTIR, and Raman analysis confirmed the formation of bioactive apatite layer on surface of the nanoparticles after 7days of immersion. The MTT assay and acridine orange staining test using hMSCs suggested the non-toxicity and osteogenic ability of as-synthesized FA nanoparticles. Based on the proposed synthesis mechanism, the deep eutectic system played a ternary role in synthesis of FA nanoparticles providing the synthesis environment, reactive calcium sites, and steric-electrostatic stabilization by which it can control the growth of as-formed FA particles in the nanometer size-range.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
