Abstract
Deep Brain Stimulation Target Selection in an Advanced Parkinson’s Disease Patient with Significant Tremor and Comorbid Depression
Highlights
Clinical Vignette: A 67-year-old female with advanced Parkinson’s disease (PD), medically refractory tremor, and a history of significant depression presented for evaluation of deep brain stimulation (DBS) candidacy
A 67-year-old right-handed female presented for evaluation of deep brain stimulation (DBS) surgery candidacy for advanced Parkinson’s disease (PD)
To address the totality of motor fluctuations in advanced PD with DBS, clinicians have favored the implantation of the globus pallidus interna (GPi) and subthalamic nucleus (STN), at varying rates over time
Summary
A 67-year-old right-handed female presented for evaluation of deep brain stimulation (DBS) surgery candidacy for advanced Parkinson’s disease (PD). Her symptoms progressed to include severe bilateral tremor with mild rigidity, bradykinesia, and shuffling gait She had a robust levodopa response that waned over time, such that each dose of carbidopa–levodopa gave her approximately 2 hours of medication-on time. Her tremor remained significant in spite of medication and interfered with daily activities such as cooking, using utensils, and holding cups. Her medications included carbidopa–levodopa, amantadine, rotigotine, and pramipexole (levodopa daily dose equivalent 920mg). Her history was complicated by depression with two prior episodes of possible suicide attempt. Testing did reveal a concern for her history of suicide attempt and her insight into its causes
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
