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Abstract
BackgroundDystonia is common in Parkinson’s disease (PD) patients, affecting about 30% of them. Bilateral subthalamic nucleus deep brain stimulation (DBS) can sometimes lead to dystonia, but this relationship is not well understood. ObjectiveTo provide a better understanding of dystonia's causes and its connection to deep brain stimulation. MethodsWe conducted a retrospective analysis of clinical data from 80 PD patients who underwent bilateral subthalamic nucleus stimulation, focusing on dystonia before and after surgery and its relation to medication state (on/off-dystonia). ResultsAfter deep brain stimulation, off-dystonia had a higher recovery rate than on-dystonia (43.5% versus 9.1%). Among patients suffering for on-dystonia, 74.4% had it for the first time after-surgery; these patients assumed higher doses of levodopa before DBS. ConclusionsPatients with off-dystonia before surgery tend to improve after DBS. Otherwise, deep brain stimulation could have the role of “additive boost” in the process of sensitization of striato-pallidal pathways and lead to on-dystonia in particular patients.
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