Deep Brain Stimulation for Ischemic Stroke Rehabilitation: from Rodents to Human

Abstract

Ischemic stroke survivors often suffer from severe disability and impaired quality of life, and the current treatments are inadequate. Deep brain stimulation (DBS) is a promising strategy to enhance recovery and alleviate symptoms, as it can modulate the electrical activity of neural circuits and facilitate neuroprotection and regeneration. In this review, we conducted a comprehensive literature search and summarized the chronic sequelae and mechanisms of ischemic stroke. Then we discuss the common targets and outcomes of DBS in preclinical and clinical studies, as well as the challenges and opportunities of DBS for ischemic stroke treatment.