Abstract
Summary. Twenty‐two estimates of Cr red‐cell survival in normal subjects, using the ‘citrate‐wash’ method of labelling, are described; results obtained with this method are shown to have given closely similar results in three different laboratories. By contrast, methods in which 51Cr is added to ACD blood have given a much wider range of normal values.In 14 patients red‐cell survival was estimated simultaneously with DF32P and 51Cr, the latter results being corrected for Cr elution using empirical factors. Estimates of mean red‐cell life‐span by the two methods agreed fairly closely. It is concluded that when 51Cr is used as a red‐cell label, the citrate‐wash method, or some other method which has also been shown to give reproducible results in different laboratories, should be used and the results should then be corrected so as to obtain an estimate of mean life‐span. Such estimates should be more useful in clinical practice than uncorrected Cr survival data.
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