Dectin-1 predicts adverse postoperative prognosis of patients with clear cell renal cell carcinoma.

Yu Xia,Ying Xiong,Qi Bai,Wei Xi,Li Liu,Jianming Guo,Yang Qu,Qilai Long,Jiejie Xu,Jiajun Wang

doi:10.1038/srep32657

Abstract

Dectin-1, a classical pattern-recognition receptor, was now identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. The aim of this study was to assess the clinical significance of dectin-1 expression in 290 patients with clear cell renal cell carcinoma (ccRCC) through immunohistochemistry on tissue microarrays. We found that dectin-1 was predominantly expressed on ccRCC cells, in accordance with several other online databases. Moreover, Kaplan-Meier method was conducted and high expression of tumoral dectin-1 was associated with shorter patient recurrence free survival (RFS) and overall survival (OS) (P < 0.001 for both). In multivariate analyses, tumoral dectin-1 expression was also confirmed as an independent prognostic factor for patients’ survival together with other clinical parameters (P < 0.001 for RFS and OS). After incorporating these characteristics including tumoral dectin-1 expression, two nomograms were constructed to predict ccRCC patients’ RFS and OS (c-index 0.796 and 0.812, respectively) and performed better than existed integrated models (P < 0.001 for all models comparisons). In conclusion, high tumoral dectin-1 expression was an independent predictor of adverse clinical outcome in ccRCC patients. This molecule and established nomograms might help clinicians in future decision making and therapeutic developments.

Highlights

Dectin-1, a classical pattern-recognition receptor, was identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production
For tumoral dectin-1 expression, the staining intensity was divided into low and high based on the cut-off value (21000) derived from total integrated optical densities (IOD) score and minimum p value method (Fig. 1E)
It has been widely accepted that cancer immunoediting and subsequent immune escape played an important role in tumor progression[12], and several recent articles reported that the molecular signatures involving inflammation and immune response in Renal cell carcinoma (RCC) were related to patient survival and drug resistance[16,17,18]

Summary

Introduction

Dectin-1, a classical pattern-recognition receptor, was identified as an important regulator in immune homeostasis and cancer immunity through its extensive ligands binding functions and subsequent cytokines production. Tumoral dectin-1 expression was confirmed as an independent prognostic factor for patients’ survival together with other clinical parameters (P < 0.001 for RFS and OS). After incorporating these characteristics including tumoral dectin-1 expression, two nomograms were constructed to predict ccRCC patients’ RFS and OS High tumoral dectin-1 expression was an independent predictor of adverse clinical outcome in ccRCC patients. This molecule and established nomograms might help clinicians in future decision making and therapeutic developments. TNM stage, Fuhrman grade and several integrated models were not enough for RCC patient outcome prediction[2]

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Conclusion