Abstract
Allergy Aberrant activation of pattern recognition receptors (PRRs) drives inflammation in autoimmune and allergic diseases. Gour et al. identified invertebrate tropomyosin from house dust mites and shrimp as a ligand for dectin-1. Dectin-1 is a PRR that recognizes fungal β-glucans in antifungal immune responses. Engagement of dectin-1 by invertebrate tropomyosins limited type 2 inflammation, and dectin-1–deficient mice were more prone to allergic airway inflammation. Furthermore, expression of dectin-1 was repressed in allergic individuals. Thus, dectin-1 is important in limiting allergic responses. Sci. Immunol. 3 , eaam9841 (2018).
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