Decreases in Oral Tissue Blood Flow Induced by Remifentanil Are Not Accompanied by Deterioration of Oral Tissue Oxygen Tension in Rabbits

Abstract

The purpose of this study was to investigate the effects of remifentanil infusion on tissue blood flow and tissue oxygen tension in the mandibular bone marrow and masseter muscle in rabbits. In addition, changes in tissue oxygen consumption in those tissues during remifentanil infusion were investigated. Sixteen male tracheotomized Japanese White rabbits were anesthetized with sevoflurane under mechanical ventilation. Under oxygen and air inhalation, fraction of inspiratory oxygen was set at 0.4 and remifentanil was infused at a rate of 0.4μg ∙ kg-1 ∙ min-1. Measurements were performed before remifentanil infusion, 20minutes after the start of remifentanil infusion, and 20 and 60minutes after the completion of remifentanil infusion (n=8). The observed variables included heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), mandibular bone marrow tissue blood flow (BBF), masseter muscle tissue blood flow (MBF), mandibular bone marrow tissue oxygen tension (PbO2), and masseter muscle tissue oxygen tension (PmO2). Another 8 rabbits were observed for arterial pH, lactate, base excess (BE), and tissue oxygen consumption in the region from which the retromandibular vein received venous blood. Measurements were performed before remifentanil infusion and 20minutes after the start of remifentanil infusion. HR, SBP, DBP, MAP, BBF, and MBF decreased during remifentanil infusion. PbO2 increased 20minutes after remifentanil infusion and returned to almost the baseline value 60minutes after remifentanil infusion. PmO2 did not change throughout the experiment. The difference between the arterial oxygen content of the femoral artery and the venous oxygen content of the retromandibular vein decreased during remifentanil infusion. Arterial pH, lactate, and BE did not change during remifentanil infusion. Remifentanil decreased BBF and MBF but did not decrease PbO2 and PmO2. It is suggested that tissue oxygen consumption decreased during remifentanil infusion.