Abstract
Sticky platelet syndrome has been described as a hereditary thrombophilic condition. The aim of this study is to identify the presence of platelet hyperaggregability in patients who have experienced thrombosis. Light-transmittance platelet aggregometry was used to assess for spontaneous platelet aggregation, aggregation in response to full and low-dose (LD) epinephrine (Epi) and adenosine diphosphate, as well as arachidonic acid, and identify a distinct pattern of platelet hyperaggregability. Light-transmittance platelet aggregometry results were correlated with PFA-100® (Dade-Behring, Marburg, Germany) results, when available. An exaggerated response to LD Epi was found in 68% of patients with thrombosis compared to only 36% of healthy controls (P=0.034). Patients with thrombosis, either arterial or venous, demonstrated an exaggerated response to LD Epi nearly twice as frequently as healthy controls, even without significant family history of thrombophilia or other known risk factors for thrombosis. This suggests that platelet hyperaggregability may be multifactorial in nature and not necessarily hereditary.
Highlights
Medical Center were included in this retro- imens were drawn into sodium citrate (3.2%)spective investigation (n=130)
The aim of this study is to use LTA to assess for spontaneous platelet aggregation, aggregation in response to full and low-dose Epi and ADP, as well as aggregation in response to arachidonic acid (AA), and identify a distinct pattern of platelet aggregation in patients without known risk factors who have experienced thrombosis
Syndrome (SPS), has only been described in a review of institutional medical records, Platelet-rich plasma (PRP) was prepared by few studies, which mainly consist of case responses to a LTA patient questionnaire sub- centrifugation at 1000 rpm for 10 minutes and reports without sufficient patient numbers. mitted with the specimen requisition, and/or platelet-poor plasma (PPP) was prepared by re
Summary
Medical Center were included in this retro- imens were drawn into sodium citrate (3.2%)spective investigation (n=130). Syndrome (SPS), has only been described in a review of institutional medical records, Platelet-rich plasma (PRP) was prepared by few studies, which mainly consist of case responses to a LTA patient questionnaire sub- centrifugation at 1000 rpm for 10 minutes and reports without sufficient patient numbers. The dered the recognition of platelet hyperaggrega- patient questionnaire documented family platelet count was adjusted to between bility as an important risk factor for thrombo- history of thrombosis. While platelet aggregometry (LTA) is con- included history of bleeding, myeloprolifera- PPP. Platelet aggregation was performed using sidered the gold standard assay to detect qual- tive neoplasms or known coagulation disorders a BioData-PAP-4 aggregometer (Bio/Data itative platelet hypofunction, at our institution, (e.g. Factor V Leiden). Little data is avail- neous aggregation, aggregation in response to nists at doses recommended by the manufacable to support the utility of such a panel in the full and LD Epi and ADP, as well as aggregation turer, was determined: 500 μg/mL of AA, 20 μM evaluation of hyperaggregable platelets
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