Abstract
Alteration of carbohydrate moieties of glycoproteins has been studied during differentiation of F9 embryonal carcinoma cells to parietal endodermal cells induced by retinoic acid and dibutyryl cyclic AMP. Synthesis of large-molecular-weight glycopeptides, which were labeled with fucose and galactose and belonged to lactosaminoglycan, sharply decreased in parallel to the morphologically distinct differentiation of the embryonal carcinoma cells. As a result of differentiation, the amount of fucose in the particulate fraction of the cells slightly decreased on the basis of the protein content.
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