Abstract
BackgroundUnilateral cerebral cortical encephalitis (UCCE) with myelin oligodendrocyte glycoprotein (MOG) antibody comprises a new spectrum of disease entities that are characterized by unilateral cerebral cortical T2-weighted fluid-attenuated inversion recovery (T2 FLAIR) hyperintense lesions on MRI. MethodsIn this retrospective study, the brain MRI of 39 consecutive Japanese patients with anti-MOG antibody-associated UCCE was examined. ResultsWe found that 37 patients (95%) also presented with T2 FLAIR hypointensity in subcortical white matter that was adjacent to the cortical lesions. ConclusionT2 FLAIR hypointensity in subcortical white matter is a characteristic finding in anti-MOG antibody-associated UCCE that might develop secondary to cortical lesions.
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