Abstract
AimThe inflammatory response, initiated by neutrophil and monocyte adhesion to endothelial cells, is important in the pathogenesis of acute coronary syndromes. Platelets play an important role in inflammatory process by interacting with monocytes and neutrophils. In this study, we investigated the effect of tirofiban on the levels of cell adhesion molecules (soluble intercellular adhesion molecule-1, sICAM-1, and vascular cell adhesion molecule-1, sVCAM-1) in patients with unstable angina pectoris (AP).MethodsThirty-five patients with unstable AP (Group I), ten patients with stable AP (Group II) and ten subjects who had angiographycally normal coronary arteries (Group III) were included the study. Group I was divided into two subgroups for the specific treatment regimens: Group IA (n = 15) received tirofiban and Group IB (n = 20) did not. Blood samples for investigating the cell adhesion molecules were drawn at zero time (baseline; 0 h) in all patients and at 72 h in Group I.ResultsThe baseline levels of sICAM-1 and sVCAM-1 were higher in Group I than in Groups II and III. They were higher in Group IA than in Group IB. However, the sICAM-1 and sVCAM-1 levels decreased significantly in Group IA after tirofiban infusion. In contrast, these levels remained unchanged or were increased above the baseline value in Group IB at 72 h.ConclusionThe levels of cell adhesion molecules in patients with unstable AP decreased significantly after tirofiban infusion. Inhibition of platelet function by specific glycoprotein IIb/IIIa antagonists may decrease platelet-mediated inflammation and the ischemic end-point.
Highlights
The inflammatory response, initiated by neutrophil and monocyte adhesion to endothelial cells, is important in the pathogenesis of acute coronary syndromes, especially unstable angina pectoris (AP) [1,2,3]
Tirofiban blocks glycoprotein (GP) IIb/IIIa receptors and prevents fibrinogen binding to platelets
Platelets play an important role in inflammatory process by interacting with monocytes and neutrophils [14]
Summary
The inflammatory response, initiated by neutrophil and monocyte adhesion to endothelial cells, is important in the pathogenesis of acute coronary syndromes, especially unstable angina pectoris (AP) [1,2,3]. Soluble intercellular adhesion molecule-1 (sICAM-1) and vascular cell (page number not for citation purposes). Thrombosis Journal 2004, 2 http://www.thrombosisjournal.com/content/2/1/4 adhesion molecule-1 (sVCAM-1) are expressed on endothelial cell membranes and are responsible for the attachment of neutrophils, monocytes and lymphocytes [4,5,6]. Tirofiban blocks glycoprotein (GP) IIb/IIIa receptors and prevents fibrinogen binding to platelets. Platelets play an important role in inflammatory process by interacting with monocytes and neutrophils [14].
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