Abstract
BackgroundFunctional TRIB3 Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent TRIB3 Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis.MethodsA total of 518 unrelated Chinese subjects consisted of control (n = 258) and MetS (n = 260) groups. Clinical and biochemical characteristics were collected. The level of serum obestatin was measured. Genotype the functional TRIB3 Q84R polymorphism. All subjects underwent ultrasonography to determine carotid intima-media thickness (IMT).ResultsSerum obestatin was significantly decreased in MetS as compared with the control group (P = 0.042). Among the MetS group participants possessing RR84 genotype had significantly lower levels of serum obestatin than those with QQ84 or QR84 genotypes (P = 0.008, P = 0.043) with similar significant difference among the control group. Factorial analyses showed statistically significant interactions between MetS and RR84 genotype (P = 0.009 for interaction for obestatin). On correlation analysis, obestatin correlated negatively with homeostasis model assessment insulin resistance (r = -0.163, P = 0.010) and IMT (r = -0.256, P = 0.011). On partial analyses, obestatin negatively correlated with IMT(r = -0.259, P = 0.024) after controlling for the confounding factors.ConclusionMetS individuals with TRIB3 RR84 genotype demonstrated further decreased serum obestatin. Decreased serum obestatin might in part exacerbate insulin resistance and carotid atherosclerosis.
Highlights
The existence of metabolic syndrome (MetS) implies a shift from a pathophysiology concept based on metabolic abnormalities resulting from an insulin-resistant state to an epidemiological construct based on abdominal obesity and crude correlates of the features of insulin resistance
We aimed to investigate the role of obestatin in MetS and carotid atherosclerosis under the background of TRIB3 Q84R polymorphism by casecontrol study
Effects of TRIB3 polymorphism on serum obestatin Among the control group, the obestatin concentrations of QQ84, QR84 and RR84 were 151.36 ± 11.75, 102.33 ± 14.45 and 95.50 ± 17.39, respectively; significant differences were observed between groups
Summary
The existence of metabolic syndrome (MetS) implies a shift from a pathophysiology concept based on metabolic abnormalities resulting from an insulin-resistant state to an epidemiological construct based on abdominal obesity and crude correlates of the features of insulin resistance. Excessive circulating adipocytokines might provide pathways linking abdominal obesity to insulin resistance, Characteristics Control group MetS group P (n = 258) (n = 260). Sex (male/female) Age (years) 54 ± 8 55 ± 9 WC (cm) 82.08 ± 7.69. Functional TRIB3 Q84R polymorphism has been associated with insulin resistance. Obestatin, improving insulin resistance, exerts obscure effects on metabolic syndrome (MetS) and carotid atherosclerosis. Aims to investigate whether the prevalent TRIB3 Q84R polymorphism has profound implications for alterations of serum obestatin and what effect obestatin exerts on carotid atherosclerosis
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