Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery

Weijun Huang,Huajun Xu,Jian Guan,Zhiyuan Song,Yupu Liu,Hongliang Yi,Jianyin Zou,Kaifeng Guo,Shankai Yin,Haoyong Yu

doi:10.1038/s41598-021-81379-1

Weijun Huang, Huajun Xu + Show 8 more

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https://doi.org/10.1038/s41598-021-81379-1

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Abstract

Obesity is strongly correlated with obstructive sleep apnea (OSA), and bariatric surgery can effectively treat obesity and alleviate OSA. However, the contributing factors are still unclear. We aimed to explore the relationship between betatrophin and OSA in patients undergoing Roux-en-Y gastric bypass (RYGB) surgery. Our study consisted of thirty-seven individuals with OSA and type 2 diabetes (16 males, 21 females) undergoing RYGB surgery. The polysomnography test, anthropometric results, serum betatrophin, and abdominal magnetic resonance images were evaluated both before and 1 year after RYGB surgery. Factors that may correlate with the alleviation of OSA were investigated. In our study, RYGB surgery significantly decreased apnea hypopnea index (AHI) and serum betatrophin concentration (p < 0.001). The abdominal visceral fat area, subcutaneous fat area and HOMA-IR were also significantly decreased (p < 0.001). The preoperative AHI, postoperative AHI and the change in AHI were significantly correlated with the preoperative betatrophin, postoperative betatrophin and the change in betatrophin, respectively (p < 0.05). These correlations were still significant after adjustment for other risk factors. The change in betatrophin was also independently associated with the change in minimum oxygen saturation (p < 0.001). Our data might indicate that serum betatrophin was significantly independently correlated with the improvement of OSA after bariatric surgery.

Highlights

Obesity is strongly correlated with obstructive sleep apnea (OSA), and bariatric surgery can effectively treat obesity and alleviate OSA
Obstructive sleep apnea (OSA) is a common disease characterized by recurrent episodes of partial or complete airway obstruction resulting in hypoxemia, hypercapnia, and respiratory a rousal[1]
Obesity is considered the strongest risk factor for OSA, because obesity-related systemic inflammatory mediators, localization of excess adipose tissue, reduced chest wall compliance, disturbances in the relationship between respiratory drive and load compensation, reductions in functional residual capacity and hormonal changes may have adverse effect in pharyngeal neural and mechanical control, and weight loss could significantly alleviate the severity of OSA for these possible m echanisms[4]

Summary

Introduction

Obesity is strongly correlated with obstructive sleep apnea (OSA), and bariatric surgery can effectively treat obesity and alleviate OSA. RYGB surgery significantly decreased apnea hypopnea index (AHI) and serum betatrophin concentration (p < 0.001). Our data might indicate that serum betatrophin was significantly independently correlated with the improvement of OSA after bariatric surgery. Obesity is considered the strongest risk factor for OSA, because obesity-related systemic inflammatory mediators, localization of excess adipose tissue, reduced chest wall compliance, disturbances in the relationship between respiratory drive and load compensation, reductions in functional residual capacity and hormonal changes may have adverse effect in pharyngeal neural and mechanical control, and weight loss could significantly alleviate the severity of OSA for these possible m echanisms[4]. Our previous study indicated a significant decrease in serum betatrophin after Roux-en-Y gastric bypass (RYGB) surgery[14]. This study was performed to evaluate the changes in serum betatrophin in obese patients with OSA after RYGB surgery, and to examine any association between serum betatrophin and OSA

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