Abstract
Background: Narrowband ultraviolet B (NB-UVB) phototherapy is widely used for the treatment of vitiligo and chronic inflammatory skin disorders. In addition to its therapeutic effects in skin disorders, NB-UVB phototherapy has been shown to increase the serum vitamin D concentration. Objectives: This study investigated the incidence of major osteoporotic fractures in patients with vitiligo after NB-UVB phototherapy. Methods: A nationwide population-based retrospective cohort study was conducted using the Korean National Health Insurance claims database (2007-2017). The study included patients who had undergone ≥ 100 phototherapy sessions (Phototherapy group) or < 3 phototherapy sessions (No phototherapy group). Using 1:2 propensity score matching, the groups were matched for age, sex, and insurance type, and for comorbidities. Results: The overall risk of osteoporotic fracture was significantly lower in the Phototherapy group compared to the No phototherapy group (hazard ratio [HR] = 0.745, 95% confidence interval [CI] = 0.602-0.921). In subgroup analyses, the risk was significantly lower in the female and older age groups. Conclusion: The risk of major osteoporotic fractures was lower in patients with vitiligo treated with long-term NB-UVB phototherapy.
Published Version
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