Abstract
BackgroundTo identify thickness variations in the retinal nerve fiber layer around the optic disc and macula in patients with cerebral vein thrombosis (CVT) without papilledema.MethodsThis study included 28 patients with CVT diagnosis and appropriate treatment. Detailed ophthalmologic examination found bilateral vision 10/10, vision field test normal and fundus examination found no papilledema images. The patients had macular and optic retinal nerve fiber layer thickness (RNFL) measured with spectral domain-optical coherence tomography (SD-OCT) (Optovue, Fremont, CA). Patients had retinal nerve fiber thickness compared with a control group.ResultsWhen the effect on the macula and RNFL near the optic nerve disk is investigated, there was significant thinning identified in the macula inferior inner, temporal inner, superior inner and temporal outer quadrants (p = 0.009, 0.001, 0.026, 0.014, respectively) and in the inferior temporal quadrant of the optic nerve disk (p = 0.020) in CVT patients compared to normal individuals.ConclusionsEven after appropriate treatment of CVT patients, axonal loss was identified with OCT. As a result, it may be important to use OCT measurements to monitor CVT treatment.
Highlights
To identify thickness variations in the retinal nerve fiber layer around the optic disc and macula in patients with cerebral vein thrombosis (CVT) without papilledema
Average Peripapillary retinal nerve fiber layer thickness (RNFL) thickness in patients with CVT and healthy volunteers We found that inferior temporal (IT) part of the peripapillary RNFL were significantly thinner in the CVT group versus to those in the healthy control group (p = 0.020)
This study investigated the macula and optic nerve disc RNFL thicknesses in patients with previous CVT diagnosis and treatment, with no vision complaints or papilledema at time of examination and identified that there was significant thinning in the inferior inner macular thickness (IIM), Temporal inner macular thickness (TIM), superior inner macular thickness (SIM) and Temporal outer macular thickness (TOM) segments of the macula and the IT sector of the optic nerve disc compared to normal individuals
Summary
To identify thickness variations in the retinal nerve fiber layer around the optic disc and macula in patients with cerebral vein thrombosis (CVT) without papilledema. Thrombosis of the cerebral veins and sinuses (CVT) is a rare cerebrovascular disease, that may become significant with missed or late diagnosis. It may be observed in all age groups, more commonly in very young and middleaged individuals and mainly affects women.. The aim of this study is to assess optic disc retinal nerve fiber and macula thickness variations in patients with CVT without papilledema after appropriate treatment. To the best of our knowledge, the present study is the first to evaluate the posterior ocular segment changes in patients with CVT using optical coherence tomography (OCT) or traditional imaging modalities
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