Abstract
A microsomal preparation from larvae of Drosophila melanogaster readily incorporated a 14C-amino acid mixture into its protein. Amino acid incorporation by microsomes from adult organisms, however, declined markedly with age. The decline in amino acid incorporation did not appear to be due to decreases in ribosomes or messenger RNA, since ribosome levels decreased only 6%, while incorporation decreased more than 70%, and only a 23% decrease in polysome-bound RNA could be detected. However, the ppolyuridylate-promoted incorporation of 14C-phenylalanine into polypeptide exhibited a sharp, age-related decline, indicating that some component of the translation system, other than messenger RNA, is responsible for the observed decline in protein synthesis
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