Abstract
The differences in the immune responses in mice fed sesame oil diets and those fed sesamin may be attributed to the presence of other lignans in the non-fat portion of the oil. The fatty acid composition (mean ± SD mol. %) of liver membrane phospholipids and the levels of endotoxin-induced prostaglandin (PG) E 2, interleukin (IL)-6, IL-10, IL-12 and tumor necrosis factor (TNF)-α were determined in mice fed diets supplemented with 5% safflower oil (SO) in the absence or presence of 1% sesamol. The levels of dihomo-γ-linolenic acid (20:3ω6) were markedly higher (P<0.025) in the livers from mice fed sesamol supplemented SO diets (1.6 ± 0.1) compared to the controls (1.4 ± 0.1). These data suggest that sesamol or its metabolite could inhibit the in vivo delta5 desaturation of ω6 fatty acids. Further, in animals fed sesamol supplemented SO diets, the levels of PGE2(228 ± 41 pg/ml) were markedly lower (P<0.01) compared to those fed SO diet alone (1355 ± 188 pg/ml). Concomitantly, the concentrations of IL-6 were also lower (P<0.01) in mice fed sesamol diet (63 ± 11 ng/ml) compared to the controls (143 ± 22 ng/ml). A marked reduction in the levels of PGE2in animals fed sesamol diets suggests that sesamol or its metabolite could inhibit the activity of cycloxygenase enzyme.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.