Decreased Na+K+ATPAse Activity is Correlated With Childhood Trauma in Bipolar Disorder Patients

Samira Valvassori,Fernanda F Gava,Luiz F Quadros,Thiani Daminelli,Luciano K Jornada,Tamires R Pacheco,Mario F Juruena,João Quevedo

doi:10.1016/j.biopsych.2020.02.691

Decreased Na+K+ATPAse Activity is Correlated With Childhood Trauma in Bipolar Disorder Patients

Samira Valvassori, Fernanda F Gava + Show 6 more

https://doi.org/10.1016/j.biopsych.2020.02.691

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Journal: Biological psychiatry

Publication Date: May 1, 2020

Affiliation: Universidade do Extremo Sul Catarinense, Universidade do Sul de Santa Catarina, Centro Universitário do Espírito Santo, South London and Maudsley NHS Foundation Trust, The University of Texas MD Anderson Cancer Center

#Bipolar Disorder Pathophysiology #Early Life Stress + Show 8 more

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Abstract

Early life stress (ELS) is associated with a higher risk of developing psychopathologies in adult life, such as bipolar disorder (BD). A previous study demonstrated that ELS induces a decrease in Na+K+ATPase. Also, decreases in Na+K+ATPase activity is one of the leading theories about BD pathophysiology. Even though the ELS and Na+K+ATPase seem to play a pivotal role in BD etiology and pathophysiology, the connection between both of them is still not clear. The present study aims to investigate the effects of ELS on Na+K+ATPase activity in erythrocytes from BD patients and healthy controls.

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