Abstract
Treatment with a novel immunomodulator called linomide resulted in highly reduced levels of pathogenic anti-DNA antibodies in MRL-lpr/lpr mice compared to untreated mice. This reduction occurred without altering the total levels of serum immunoglobulins, implying that the compound does not have any direct B-cell suppressive effect. The possible role of T cells in regulating autoreactive B-cell clones is discussed.
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