Decreased levels of GABA in the inferior colliculus of the epilepsy-prone hamster (GPG/Vall)

Verónica Fuentes-Santamaría,Juan Carlos Alvarado,Antonio S Herranz,Natividad García-Atarés,Dolores E López

doi:10.1016/j.eplepsyres.2008.02.003

Decreased levels of GABA in the inferior colliculus of the epilepsy-prone hamster (GPG/Vall)

Verónica Fuentes-Santamaría, Juan Carlos Alvarado + Show 3 more

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https://doi.org/10.1016/j.eplepsyres.2008.02.003

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Journal: Epilepsy research	Publication Date: Mar 26, 2008
Citations: 10	License type: cc-by-nc-nd

Affiliation: Wake Forest University, University of Valladolid, Instituto de Estudios de Ciencias de la Salud de Castilla y León, Universidad de Salamanca

#Central Nucleus Of The Inferior Colliculus #High Performance Liquid Chromatography + Show 8 more

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Abstract

Abnormalities in GABA levels in the central nucleus of the inferior colliculus (CNIC) of the epilepsy-prone hamster (GPG/Vall) were evaluated by using immunohistochemistry, densitometry and high performance liquid chromatography (HPLC). These findings demonstrate a decrease both in GABA immunostaining (neuropil and neurons) and in GABA concentration (HPLC) in the CNIC of the epileptic hamster compared to control animals. These decreases may reflect a reduced availability of this neurotransmitter that may act as an audiogenic seizure-initiating factor.

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