Decreased levels of fibrinogen in very high parity women

Abstract

Objectives: To evaluate coagulation parameters in healthy pregnant grand grand multiparous women. Study design: Prothrombin time (PT), activated partial thromboplastin time (PTT), fibrinogen, d-dimer, albumin and blood lipids were prospectively determined in 50 pregnant grand grand multiparas (≥9 deliveries) and 50 age-matched pregnant women with low parity (≤3 deliveries). Results: The average concentrations of fibrinogen in the grand grand multiparas were 4.0±0.6 as compared to 4.7±0.7 g/l in the control group ( P<0.001). In both groups d-dimer levels were >1000 ng/ml and the concentrations of albumin, triglycerides, cholesterol, high-density lipoprotein (HDL) were not significantly different. Conclusions: In healthy pregnant grand grand multiparous women fibrinogen levels are lower than in age-matched women with low parity. These changes are not directly associated with lipids metabolism during pregnancy.