Abstract
Purpose: Obesity is a major risk factor in the pathogenesis of osteoarthritis (OA). The infrapatellar fat pad (IFP) within the knee has been implicated in contributing to knee OA development by the secretion of inflammatory mediators. Here, we developed a novel transgenic mouse model of localised lipodystrophy of intra-articular adipose tissue to investigate whether alterations in adipose tissue in the knee can affect joint homeostasis and OA development.
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