Abstract
Summary Accelerated rejection of male skin isografts by C57BL/6 female mice occurs as a consequence of previous injection of 20 million male CBA spleen cells by either the i.p. or i.v. route. However, if the test mice are immunized against CBA isoantigens from female donors 20 days before inoculation of the male CBA cells, rejection of the test grafts is significantly delayed. The inhibitory effect of prior CBA isoimmunization on sensitization to the male factor does not occur when isologous male cells are mixed with CBA female spleen cells and inoculated. These results are interpreted as evidence that the secondary response to the CBA isoantigens is capable of blocking access of the male antigen to those sites in which the primary response can be initiated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
