Abstract
The elimination of the antimalarial drug pyrimethamine was studied in isolated liver preparations from young rats (80–100 g) infected with merozoites of Plasmodium berghei two weeks earlier. Perfusate half-life of pyrimethamine was increased in livers from M.I. rats ( t 1/2 βcontrol group= 56 ± 11min vs M.I. group= 101 ± 12,P< 0.01), reflecting a decrease in hepatic clearance (3.6 ± 1.1ml/min vs 1.9 ± 0.5ml/min, P< 0.01). There was no significant difference in volume of distribution between livers from M.I. and control groups. Intrahepatic concentration of unchanged drug at 3 hr was 4–5-fold greater in livers from infected rats (control group= 4725 ± 2287ng/ml vs M.I. group= 22,324 ± 6824ng/ml), while liver: perfusate concentration ratios were not significantly different (control group= 30.8 ± 24.1 vs. M.I. group= 35.6 ± 20.3). We conclude that the hepatic elimination of pyrimethamine is substantially impaired in the malaria-infected rat.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
