Abstract
Decreased heart rate variability (HRV) is associated with increased mortality risk in various diseases. The objective of this investigation:to study HRV in patients with sickle cell anemia (SCA) and to assess the effect of pulmonary arterial hypertension (PAH) on HRVin these patients. Materials and methods. HRV registration and Doppler echocardiographic assessment of systolic pulmonary arterialpressure (PAP) was carried out in 61 stable patients with SCA and 24 healthy subjects. Results. Low frequency power (LFP) and highfrequency power (HFP) were decreased in SCA patients compared to healthy subjects. Among SCA patients, PAH patients had lower LFP and HFP than patients without PAH. In SCA patients, systolic PAP showed significant negative correlation with LFP and HFP.Conclusion. HRV is significantly decreased in SCA patients, especially in those with PAH. HRV may be particularly useful in early detection of PAH patients who may have worse prognosis and higher mortality risk.
Highlights
§ АРИТМИИ СЕРДЦА Low frequency power (LFP) and high frequency power (HFP) than patients without pulmonary arterial hypertension (PAH)
heart rate variability (HRV) is significantly decreased in sickle cell anemia (SCA) patients, especially in those with PAH
HRV may be useful in early detection of PAH patients who may have worse prognosis and higher mortality risk
Summary
§ АРИТМИИ СЕРДЦА LFP and HFP than patients without PAH. In SCA patients, systolic PAP showed significant negative correlation with LFP and HFP. 2, 3: СКА – серповидноклеточная анемия; ЛАГ – легочная артериальная гипертензия; ИМТ – индекс массы тела; САД – систолическое артериальное давление; ДАД – диастолическое артериальное давление; ЧСС – частота сердечных сокращений; ЧД – число дыханий; ЛП – левое предсердие; МЖП – межжелудочковая перегородка; ЛЖ – левый желудочек; КДР ЛЖ – конечный диастолический размер левого желудочка; КСР ЛЖ – конечный систолический размер левого желудочка; ФВ ЛЖ – фракция выброса левого желудочка; ИММЛЖ – индекс массы миокарда левого желудочка; sPAP – систолическое давление в легочной артерии; нд – недостоверно. Однако у пациентов с СКА с ЛАГ по сравнению с группой пациентов с СКА без ЛАГ толщина МЖП, КДР ЛЖ, КСР ЛЖ, индекс ММЛЖ и sPAP были выше, а уровни насыщения кислородом артериальной крови – ниже (p
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