Abstract
The ability of the liver to reduce the intensity of the graft versus host (GVH) reaction has been investigated in F 1 hybrid rats implanted with parental lymph nodes, spleen, thymus or Peyer's patches. Intrahepatic and intrarenal tissue implantations were compared using classical GVH criteria. The intrahepatic implantation of tissues well known to induce a GVH reaction suppressed the mortality observed after intrarenal implantation whereas the number of paravascular infiltrates (PVI) in the liver was increased. These results confirm the importance of portal drainage in organ transplantation and suggest a new site of implantation for lymphoid cells. These observations are compatible with the presence in the liver of blocking complexes and/or the existence of a splenohepatic suppressor axis.
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