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Abstract
Background Thymic Stromal Lymphopoietin (TSLP) is a potent immunomodulatory cytokine involved in Th2-mediated immune responses and homeostatic T-cell expansion. Reduced TSLP expression by intestinal epithelial cells was recently shown to lead to reduced Th2 responses and development of Th1-mediated experimental colitis. Additionally, TSLP is described as a proinflammatory factor in autoimmune diseases. TSLP expression was studied in salivary glands of primary Sjogren’s syndrome (pSS) patients as compared to non-SS Sicca (nSS) patients and the relationship to localand systemic disease parameters was examined.
Highlights
Thymic Stromal Lymphopoietin (TSLP) is a potent immunomodulatory cytokine involved in Th2-mediated immune responses and homeostatic T-cell expansion
TSLP was almost exclusively expressed by acinar cells in both primary Sjögren’s syndrome (pSS) and non-SS Sicca (nSS) patients
The number of TSLPexpressing cells per mm2 was significantly decreased in pSS patients as compared to nSS patients and correlated negatively to Lymphocyte Focus Score (LFS), ESR, serum IgG levels and positively to the percentage of local IgA producing plasma cells
Summary
Decreased expression of TSLP in labial salivary glands of patients with primary Sjögren’s syndrome is associated with local- and systemic disease parameters. Maarten R Hillen*, Angela Bikker, Aike A Kruize, Marion Wenting-van Wijk, Floris PJG Lafeber, C Erik Hack, Timothy RDJ Radstake, Joel AG van Roon. From 7th European Workshop on Immune-Mediated Inflammatory Diseases Noordwijk aan Zee, the Netherlands. From 7th European Workshop on Immune-Mediated Inflammatory Diseases Noordwijk aan Zee, the Netherlands. 28-30 November 2012
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