Decreased expression of the Fas ligand on peripheral blood mononuclear cells and undetectable levels of soluble Fas ligand in the serum of patients with aplastic anemia and myelodysplastic syndrome

Abstract

American Journal of HematologyVolume 62, Issue 2 p. 124-125 Letters & CorrespondenceFree Access Decreased expression of the Fas ligand on peripheral blood mononuclear cells and undetectable levels of soluble Fas ligand in the serum of patients with aplastic anemia and myelodysplastic syndrome Kenji Shinohara, Kenji Shinohara Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, JapanSearch for more papers by this authorToru Takahahi, Toru Takahahi Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, JapanSearch for more papers by this authorRyohei Nawata, Ryohei Nawata Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, JapanSearch for more papers by this authorEiichi Oeda, Eiichi Oeda Department of Medicine, Shimonoseki Kosei Hospital, Shimonoseki, JapanSearch for more papers by this author Kenji Shinohara, Kenji Shinohara Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, JapanSearch for more papers by this authorToru Takahahi, Toru Takahahi Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, JapanSearch for more papers by this authorRyohei Nawata, Ryohei Nawata Division of Hematology, Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, JapanSearch for more papers by this authorEiichi Oeda, Eiichi Oeda Department of Medicine, Shimonoseki Kosei Hospital, Shimonoseki, JapanSearch for more papers by this author First published: 04 October 1999 https://doi.org/10.1002/(SICI)1096-8652(199910)62:2<124::AID-AJH16>3.0.CO;2-JCitations: 3AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1Maciejewski J, Selleri C, Anderson S, Young NS. Fas antigen expression on CD34+ human marrow cells is induced by interferon γ and tumor necrosis factor α and potentiates cytokine-mediated hematopoietic suppression in vitro. Blood 1995; 85: 3183– 3190. Medline 2Hatake K, Tomizuka H, Ikeda M, Tsunoda JI, Hoshino Y, Otsuki T, Kasahara T, Yonehara S, Miura Y. The presence of apoptosis in refractory anemia or myelodysplasia. In: NG Abraham, editor. Molecular Biology of Haematopoiesis. Andover: Intercept; 1994. p 122– 123. 3Suda T, Okazaki T, Naito Y, Yokota T, Arai N, Ozaki S, Nakao K, Nagata S. Expression of the Fas ligand in cells of T cell lineage. J Immunol 1995; 154: 3806– 3813. Medline 4Tanaka M, Suda T, Takahashi T, Nagata S. Expression of the functional soluble form of human Fas ligand in activated lymphocytes. EMBO J 1995; 14: 1129– 1135. Medline 5Tanaka M, Itai T, Adachi M, Nagata S. Downregulation of Fas ligand by shedding. Nat Med 1998; 4: 31– 36. Medline 6Nagata S. Apoptosis by death factor. Cell 1997; 88: 355– 365. Medline 7Selleri C, Maciejewski JP, Sato T, Young NS. Interferon-γ constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition. Blood 1996; 87: 4149– 4157. Medline 8Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 181: 2029– 2036. Medline Citing Literature Volume62, Issue2October 1999Pages 124-125 ReferencesRelatedInformation