Abstract

Decreased kidney function is a putative risk factor for various cancers. However, few studies have investigated the association between a decreased estimated glomerular filtration rate (eGFR) and incident pancreatic cancer. We aimed to investigate the risk of incident pancreatic cancer according to eGFR categories. In this retrospective cohort study, we included 359721 adults who underwent health checkups in 2009 or 2010 by using the Korean National Health Insurance Database. The study population was categorized into four groups by eGFR (mL/min/1.73m2 ) using the Chronic Kidney Disease Epidemiology Collaboration equation: group 1 (eGFR<45), group 2 (eGFR ≥45 to <60), group 3 (eGFR ≥60 to <90), and group 4 (eGFR≥90). Multivariate Cox proportional hazards models were used to determine the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of pancreatic cancer until 2019 by comparing the eGFR groups. During the 3493589.05 person-years of follow-up, 1702 pancreatic cancer cases were identified. Compared with group 4 (eGFR≥90), HRs and 95% CIs for the incidence of pancreatic cancer were 1.39 (1.24-1.56) for group 3 (eGFR ≥60 to <90), 1.79 (1.47-2.16) for group 2 (eGFR ≥45 to <60), and 2.05 (1.62-2.60) for group 1 (eGFR<45) in the multivariate adjusted model. Decreased eGFR was significantly associated with an increased risk of pancreatic cancer in Korean population. Further studies are needed to investigate the relationship between a decreased eGFR and the risk of pancreatic cancer in other ethnic groups.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.