Abstract
Decorin is a small leucine-rich proteoglycan, synthesized and deposited by fibroblasts in the stroma where it binds to collagen I. It sequesters several growth factors and antagonizes numerous members of the receptor tyrosine kinase family. In experimental murine systems, it acted as a potent tumor suppressor. Examining the Human Protein Atlas online database of immunostained tissue samples we have surveyed decorin expression in silico in several different tumor types, comparing them with corresponding normal tissues. We found that decorin is abundantly secreted and deposited in normal connective tissue but its expression is consistently decreased in the tumor microenvironment. We developed a software to quantitate the difference in expression. The presence of two closely related proteoglycans in the newly formed tumor stroma indicated that the decreased decorin expression was not caused by the delay in proteoglycan deposition in the newly formed connective tissue surrounding the tumor.
Highlights
Decorin is a small stromal proteoglycan belonging to the small leucine-rich proteoglycan (SLRP) gene family
Decorin expression was compared in human urinary bladder, breast, cervix, colon, kidney, ovary, pancreas, prostate, rectum, skin, stomach, and testis tissues (Fig. 1)
We found that decorin was abundantly expressed in the stroma of all examined normal tissues and absent or significantly reduced in the corresponding tumors
Summary
Decorin is a small stromal proteoglycan belonging to the small leucine-rich proteoglycan (SLRP) gene family. It is mainly synthesized and deposited by fibroblasts and was named after its tight binding to collagen I fibers that it decorates [1,2,3]. One molecule of decoron has the capacity to interact with four to six collagen molecules [5] and plays an important role in the regulation of fibrillogenesis [6,7,8,9] It sequesters multiple growth factors, including transforming growth factor beta-1,2 (TGF-b1, -2), and myostatin [10,11,12,13] and directly antagonizes several members of the receptor tyrosine kinase (RTK) family including epidermal growth factor receptor (EGFR), insulin-like growth factor receptor I (IGF1R) and hepatocyte growth factor receptor (HGFR) [14,15,16,17].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
