Abstract
Hepatocyte nodules and hepatocellular carcinomas were induced in male Fischer rats using the resistant hepatocyte model. The immunoreactive cytosolic levels of the heme-binding Z protein (HBP) were reduced by 56% (P < 0.001; 2-tailed t-test) in early hepatocyte nodules (25 weeks) and hepatocellular carcinomas (10–12 months). This finding is in accordance with the previously reported reduced heme content of hepatocyte nodules and is consistent with the postulated role for HBP in intracellular heme transport and distribution. The immunoreactive levels of the glutathione S-transferase isozymes (GST) which like HBP bind heme, were elevated 2-fold (P < 0.01) in early and late hepatocyte nodules and were unchanged in hepatocellular carcinomas.
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