Decreased Cortical Folding of the Fusiform Gyrus and Its Hypoconnectivity with Sensorimotor Areas in Major Depressive Disorder

Abstract

Background: Neuroimaging studies have revealed abnormal cortical folding pattern and disruptive functional connectivity in major depressive disorder (MDD). Combining structure and function in the same population may further our understanding of the neuropathological mechanisms of MDD. Method: Sixty-two patients with MDD and 61 healthy controls (HCs) underwent structural and resting-state functional magnetic resonance imaging (MRI). Group differences in the cortical folding (measured by local gyrification index (LGI)) were analyzed in FreeSurfer. Taking the brain regions with significant group differences in LGI as seed regions, the resting-state functional connectivity analysis was further conducted to explore the corresponding functional connectivity alterations. Results: Comparing with HCs, patients with MDD showed significantly decreased LGI in the right fusiform gyrus (cohen's d = 0.70). In the seed-based functional connectivity analysis, we found that compared with HCs, patients with MDD showed decreased functional connections between the right fusiform gyrus with sensorimotor areas (precentral and postcentral gyrus) (cohen's d = 1.32) and right superior temporal gyrus (cohen's d = 0.94). Limitations: Main limitations are the relatively small sample size and the cross-sectional study design. Conclusion: Decreased LGI in the right fusiform gyrus, as well as decreased functional connectivity between the right fusiform gyrus and the sensorimotor area and right superior temporal gyrus, appears to play a role in the pathophysiology of MDD.