Abstract
Dan Chen1, Zheng Xiao2, Liang Wang2, Fei Xiao2, Zhi Qin Xi2, Xue Feng Wang2 and Qiao Cheng3* Author Affiliations 1Department of Neurosurgery, China 2Department of Neurology, China 3Department of Endocrine and Breast Surgery, China Received: May 15, 2019 | Published: June 06, 2019 Corresponding author: Qiao Cheng, Department of Endocrine and Breast Surgery, China DOI: 10.26717/BJSTR.2019.18.003184 Also View In:
Highlights
Epilepsy is a chronic neurological condition that affects 1% of people worldwide and is characterized by unprovoked, recurrent seizures
cerebrospinal fluid (CSF) and serum Pigment epithelium-derived factor (PEDF) were increased in drug-effective epilepsy but were dramatically decreased in drug-refractory epilepsy compared with controls
We suggest that the serum PEDF may reflect CSF PEDF
Summary
Epilepsy is a chronic neurological condition that affects 1% of people worldwide and is characterized by unprovoked, recurrent seizures. There is a link between epilepsy and brain damage. Apoptosis and glutamate neurotoxicity have been suggested to be involved in seizure-induced brain damage. It has been determined that apoptosis is involved in the death of neurons after status epilepticus [1] and after prolonged seizures in animal models [2,3,4]. Beside the modulation of caspases and Bcl-2 molecular pathways of apoptosis are recognized in human temporal lobe epilepsy (TLE) [5]. In chronic epilepsy models in rodents, there is a consistent marked increase in glutamate release during seizures [6]. In evoked seizures during surgery [7] and spontaneous
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