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Abstract
Angiotensin II (ANG) binding sites were quantified in single pituitary glands from 4-week-old and 14-week-old male spontaneously hypertensive rats (SHR) and age-matched male normotensive Wistar-Kyoto (WKY) control rats after incubation with 125I-[Sar 1]-ANG, autoradiography with computerized densitometry, and comparison to 125I-standards. The maximum binding capacity (B max) decreased while the dissociation constant (K d) for ANG increased in 14-week-old SHR when compared to age-matched WKY control rats (B ram: 265 ± 9 and 224 ± 4 fmol/mg protein; K d: 0.79 ± 0.04 and 1.14 ± 0.08 10 −9 M in WKY and SHR, respectively). Conversely, no difference between rat strains was found in 4-week-old animals. Our results suggest that pituitary ANG binding sites may play a role in the pathophysiology of established genetic hypertension.
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