Abstract
Fatigue is a health problem prevalent in modern societies. Fatigue sensation plays an important role as a biological alarm urging rest to maintain homeostasis, and clarifying the neural mechanisms related to fatigue sensations by which we decide to engage in rest is therefore essential. This study enrolled healthy male volunteers and showed that the decrease in alpha-band power as assessed by magnetoencephalography of the left Brodmann’s area (BA) 6 before perception of fatigue when a button-press based on the level of fatigue was required was smaller than that before perception of the intention to move when a voluntary button-press was required. In addition, the decrease of alpha-band power in the left BA 6 before the perception of fatigue was not altered compared with that in the right BA 6 when a button-press based on the level of fatigue was required. These results suggest that the button-press based on the perception of fatigue is not prepared before the perception of fatigue. These findings will advance the understanding of the neural mechanisms related to subjective feelings such as fatigue sensation.
Highlights
Fatigue is a health problem prevalent in modern societies[1,2,3,4,5] and the accumulation of fatigue caused by overwork can even cause death[6,7]
Whether the belief of individuals that they decided to engage in rest based on their subjective feeling of fatigue sensation is true remains unclear
It has been reported that the precision for the peak intensity estimated by spatial filtering algorism of MEG data depends on the number of time points included in the data analyzed[29]: The precision increases as the number of time points increases and reaches almost plateau at 6,000 time points
Summary
Fatigue is a health problem prevalent in modern societies[1,2,3,4,5] and the accumulation of fatigue caused by overwork can even cause death[6,7]. The neural mechanisms promoting rest based on the subjective perception of fatigue are doubtlessly important for avoiding the accumulation of fatigue. It is of great interest that the RP is observed far before the moment that the intention to move is perceived when the movement was initiated at a self-chosen moment: the intention to move is usually perceived around 200 to 300 ms before movement onset[13,14,15] This observation suggests that the neural activity related to these putative functions such as preparation for a voluntary movement, decision-related or anticipatory processes, or the propensity to act, precede perception of the intention to move when the movement was initiated at a self-chosen moment
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