Abstract
Prolonged or excessive formation and liberation of cytotoxic substances from neutrophils intensifies inflammation and the risk of tissue damage. From this perspective, administration of substances which are able to reduce activity of neutrophils and to enhance apoptosis of these cells may improve the therapy of pathological states connected with persistent inflammation. In this short review, neutrophil oxidative burst and apoptosis are presented as potential targets for pharmacological intervention. Effects of natural polyphenols (resveratrol, pterostilbene, pinosylvin, piceatannol, curcumin, N-feruloylserotonin) are summarised, considering the ability of these compounds to affect inflammation and particularly neutrophil activity. The intended neutrophil inhibition is introduced as a part of a new strategy for pharmacological modulation of chronic inflammatory processes, focused on supporting innate anti-inflammatory mechanisms and enhancing resolution of inflammation.
Highlights
REVIEW ARTICLEViera JANČINOVÁ 1, Tomáš PEREČKO 1, Juraj HARMATHA 2, Radomír NOSÁĽ 1, Katarína DRÁBIKOVÁ 1 1 Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia 2 Institute of Organic Chemistry and Biochemistry, Academy of Sciences, v.v.i., CZ-16610 Prague, Czech Republic
Prolonged or excessive formation and liberation of cytotoxic substances from neutrophils intensifies inflammation and the risk of tissue damage
Neutrophil oxidative burst and apoptosis are presented as potential targets for pharmacological intervention
Summary
Viera JANČINOVÁ 1, Tomáš PEREČKO 1, Juraj HARMATHA 2, Radomír NOSÁĽ 1, Katarína DRÁBIKOVÁ 1 1 Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Sciences, SK-84104 Bratislava, Slovakia 2 Institute of Organic Chemistry and Biochemistry, Academy of Sciences, v.v.i., CZ-16610 Prague, Czech Republic
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